B-cell infiltration and frequency of cytokine producing cells differ between localized and disseminated human cutaneous leishmaniases

B-cell infiltration and frequency of cytokine producing cells differ between localized and disseminated human cutaneous leishmaniases

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Biopsies from human localized cutaneous lesions cyspera cream where to buy (LCL n = 7) or disseminated lesions (DL n = 8) cases were characterized according to cellular infiltration,frequency of cytokine (IFN-g, TNF-alpha) or iNOS enzyme producing cells.LCL, the most usual form of the disease with usually one or two lesions, exhibits extensive tissue damage.DL is a rare form with widespread lesions throughout the body; exhibiting poor parasite containment but less tissue damage.We demonstrated that LCL lesions exhibit higher frequency of B lymphocytes and a higher intensity of IFN-gamma expression.

In both forms of the disease CD8+ were found in higher frequency than CD4+ T cells.Frequency of TNF-alpha and iNOS producing cells, as well as the frequency of CD68+ macrophages, did not differ between LCL and DL.Our findings reinforce the link between an efficient control of parasite and tissue damage, implicating higher frequency of IFN-gamma producing cells, as well as its possible counteraction by infiltrated B cells and hence ds durga hand soap possible humoral immune response in situ.